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Enabling safe and efficient drug delivery across the blood‐brain barrier (BBB) remains to be challenging. On page 36 of this issue, T. Lammers, P. Koczera, F. Kiessling, and colleagues show that polymer‐based microbubbles, containing iron oxide nanoparticles within their shell, can be employed to mediate and monitor BBB permeation. Such theranostic constructs and concepts are considered to be useful...
Efficient and safe drug delivery across the blood‐brain barrier (BBB) remains one of the major challenges of biomedical and (nano‐) pharmaceutical research. Here, it is demonstrated that poly(butyl cyanoacrylate)‐based microbubbles (MB), carrying ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles within their shell, can be used to mediate and monitor BBB permeation. Upon exposure to transcranial...
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