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Recruitment of receptors at membrane interfaces is essential in biological recognition and uptake processes. The interactions that induce recruitment are typically weak at the level of individual interaction pairs, but are strong and selective at the level of recruited ensembles. Here, a model system is demonstrated, based on the supported lipid bilayer (SLB) that mimics the recruitment process induced...
Receptor Recruitment
Ligand‐functionalized lipid vesicles bind to receptor‐functionalized supported lipid bilayers through weak, multivalent receptor‐ligand interactions. As a result of binding, surface‐bound receptors move into the area of contact – a process called “recruitment” – to increase the local receptor density and thus enhance binding. The affinity, the size and the receptor density of...
Crowding effects have a profound impact on the hierarchical organization of cellular architectures. In the fields of systems chemistry and soft matter, this effect has not received much attention so far. Here, it is explored how poly(ethylene glycol) (PEG) as a crowding agent invokes depletion forces that act on synthetic supramolecular tubes. Hence, supramolecular tubes are pushed from their random...
Understanding how influenza viruses traverse the mucus and recognize host cells is critical for evaluating their zoonotic potential, and for prevention and treatment of the disease. The surface of the influenza A virus is covered with the receptor‐binding protein hemagglutinin and the receptor‐cleaving enzyme neuraminidase, which jointly control the interactions between the virus and the host cell...
Electrochemistry provides a powerful sensor transduction and amplification mechanism that is highly suited for use in integrated, massively parallelized assays. Here, the cyclic voltammetric detection of flexible, linear poly(ethylene glycol) polymers is demonstrated, which have been functionalized with redox‐active ferrocene (Fc) moieties and surface‐tethered inside a nanofluidic device consisting...
Supramolecular chemistry provides a tool for the formation of highly ordered structures by means of noncovalent interactions. Soft supramolecular nanoparticles are self‐assembled nanoassemblies based on small building blocks and stabilized by basic noncovalent interactions, selective host–guest interactions, or a combination of different interaction types. This review provides an overview of the existing...
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