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Tumor Microenvironments
In article number 2304491, Zhiyuan Tian and co‐workers develop a metal‐organic framework (MOF)‐based nanoagent capable of sequentially killing cancer‐associated fibroblast and tumor cells via phototriggered dual‐channel generation of •OH, activating tumor immune response, and regulating tumor microenvironment, which enables the potently synergistic antitumor phototherapy.
A composite nanoagent capable of phototriggered tumor microenvironment (TME) regulation is developed based on copper (II) metal‐organic frameworks (MOFs) with encapsulation of blebbistatin (Bb) and surface modification of fibroblast activation protein‐αtargeted peptide (Tp). Tp enables active targeting of the nanoagents to cancer‐associated fibroblast (CAF) while near‐infrared light triggers Cu2+‐to‐Cu...