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We have systematically explored the Hofmeister effects of cations and anions (0.3–1.75M range) for acidic Desulfovibrio desulfuricans apoflavodoxin (net charge −19, pH 7) and basic horse heart cytochrome c (net charge +17, pH 4.5). The Hofmeister effect of the ions on protein thermal stability was assessed by the parameter dT trs /d[ion] (T trs ; thermal midpoint). We show that dT...
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