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The microfluidic designed by R. D. Kamm and co‐workers allow the formation of simultaneous or sequential concentration gradients within a 3D extracellular matrix. On page 612, these gradients can be used to investigate biological phenomena, such as the differentiation of progenitor cells into neurons as it occurs within the developing spinal cord, or the dynamics of chemotaxis when cells are exposed...
Biochemical gradients are ubiquitous in biology. At the tissue level, they dictate differentiation patterning or cell migration. Recapitulating in vitro the complexity of such concentration profiles with great spatial and dynamic control is crucial in order to understand the underlying mechanisms of biological phenomena. Here, a microfluidic design capable of generating diffusion‐driven, simultaneous...
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