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An aptamer-based electrochemical sensing platform for the direct protein detection has been developed using IgE and a specifically designed aptamer with hairpin structure as the model analyte and probe sequence, respectively. In the absence of IgE, the aptamer immobilized on an electrode surface forms a large hairpin due to the hybridization of the two complementary arm sequences, and peak currents...
A novel on/off electronic nanoswitch is for the first time described based on the conformational change of DNA sequence possessing a single guanine (G)-rich stretch. Here, a thiolated, amine-containing G-rich DNA sequence is immobilized on the surface of gold electrode by means of facile sulfur–gold chemistry, followed by being labeled with redox-active ferrocene molecules serving as the signaling...
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