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Dopamine(DA)rgic neurons are particularly vulnerable due to the presence of oxidative stress-inducing molecules such as DA, tetrahydrobiopterin, iron and tyrosine hydroxylase (TH). We have recently observed that matrix metalloproteinase-3 (MMP-3) is involved in degeneration of DArgic neurons. In the present study, we sought to explore the role of MMP-3 in DArgic neurons not exposed to apparent stress...
The dopaminergic (DArgic) neurons in the substantia nigra (SN) are particularly vulnerable to oxidative stress and during aging. The present study was undertaken in order to determine whether aging is associated with changes in the DA synthesizing enzyme tyrosine hydroxylase (TH) as early as middle age by comparing 7- and 50-week-old mice. Quantitative analysis, performed by measuring the density...
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