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Centrin binds to Rad4(XPC) and Sfi1 through the hydrophobic motif W1xxL4xxxL8 in the opposite orientation. Rad4 has one motif, but Sfi1 has approximately 20 repeats, each of which interacts with a centrin molecule.To investigate the parameters involved in centrin binding, we purified a ScSfi1 domain containing 6 repeats complexed with either yeast centrin Cdc31 or human centrin 1. The present study...
The Ca2+-binding protein centrin binds to a hydrophobic motif (W1xxL4xxxL8) included in the sequence of several cellular targets: XPC (xeroderma pigmentosum group C protein), Sfi1 (suppressor of fermentation-induced loss of stress resistance protein1), and Sac3 [the central component of the transcription and mRNA export (TREX-2) complex]. However, centrin binding occurs in a reversed orientation (L...
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