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Nicotine, an addictive substance in cigarette, triggers glutamatergic synaptic plasticity on ventral tegmental area (VTA) dopamine (DA) neurons. The functional coupling between prefrontal cortex (PFC) and VTA has been demonstrated, but little is known how PFC mediates nicotinic modulation in VTA DA neurons. In this study, we tested the hypothesis that systemic exposure to nicotine significantly increases...
This research is to develop a system to allow cancer researchers as well as drug discovery people to study drug effects in situ, real-time and at "few cells" level but large cell numbers. A microelectrode array was designed and fabricated by using silicon micromachining technology. The cancer cell NCI-H460 was attached on the Au microelectrode and the high impedance sensitivity at very "few...
A diversity guaranteed ant colony algorithm is presented by simulating the behavior of biological immune system. The algorithm adopts the immunogenic methods immune selection, immune memory, immune metabolism, density control and isolation niche technique. In each iteration of the algorithm, the solutions of the ants are selected to have crossover and mutation operations according to their quality...
The investigation of interactions between two kinds of monoclonal antibodies and SARS virus with a label-free protein array technique were presented in this paper. The performance consists of three parts: a surface modification for ligand immobilization/surface, a protein array fabrication with an integrated microfluidic system for patterning, packaging and liquid handling, and a protein array reader...
We have developed a new integrated probabilistic method for cellular function prediction by using microarray gene expression profiles, in conjunction with predicted protein-protein interactions and annotations of known proteins through an integrative statistical model. Our approach is based on a novel assessment for the relationship between correlation of two genes' expression profiles and their functional...
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