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Background
IL‐25 has been proposed to play a key role in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). This study aimed to evaluate the association of IL‐25 with the Th2‐biased inflammatory profiles in CRSwNP.
Methods
Nasal polyp (NP) tissues and control uncinate process tissues were collected from 92 patients with CRSwNP, 20 patients with chronic rhinosinusitis without...
Background
T helper type 9 (Th9) cells, a subpopulation of CD4+ T cells, play a critical role in the pathogenesis of allergic airway inflammation. However, it remains unknown whether mTORC2 regulates Th9 differentiation or function during allergic inflammation.
Methods
T‐cell‐specific Rictor‐deficient mice, a mouse model of allergic airway inflammation induced by ovalbumin (OVA) sensitization and...
BackgroundAllergic Rhinitis Control Test (ARCT) has been validated for assessing allergic rhinitis (AR) control and identifying severe AR. The aim of the study was to assess the ARCT questionnaire as a tool for stepwise pharmacotherapy.
MethodsA standard pharmacotherapy regimen from Step 1 (oral second‐generation H1 antihistamine as needed) to Step 5 (oral corticosteroid) was carried out prospectively...
BackgroundForcipomyia taiwana (biting midge) is the most prevalent allergenic biting insect in Taiwan, and 60% of the exposed subjects develop allergic reactions. Subjects with insect allergy frequently limit their outdoor activities to avoid the annoyingly intense itchy allergic reactions, leading to significant worsening of their quality of life. Allergen‐specific immunotherapy is the only known...
BackgroundA cross‐sectional retrospective study suggested a link between allergic diseases and Parkinson's disease. However, the temporal association between asthma and Parkinson's disease remains unknown.
MethodsFrom the Taiwan National Health Insurance Research Database, 10 455 patients who were diagnosed with asthma between 1998 and 2008 and aged ≥45 years and 41 820 age‐ and sex‐matched controls...
To cite this article: Kezic S, O’Regan GM, Yau N, Sandilands A, Chen H, Campbell LE, Kroboth K, Watson R, Rowland M, Irwin McLean WH, Irvine AD. Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity. Allergy 2011; 66: 934–940.
AbstractBackground: Filaggrin, coded by FLG, is the main source of several major components of natural moisturizing...
To cite this article: He S, Li T, Chen H, Ma W, Yao Q, Yang H, Wang H, Wang F, Zhao C, Yang P. CD14+ cell–derived IL‐29 modulates proinflammatory cytokine production in patients with allergic airway inflammation. Allergy 2011; 66: 238–246.
AbstractBackground: Interleukin (IL)‐29 is a newly described cytokine that has anti‐viral activity, induces tumor cell death and regulates immune function. Whether...
To cite this article: He S, Zhang H, Chen H, Yang H, Huang T, Chen Y, Lin J, Wang F, Chen X, Li T‐L, Yang P. Expression and release of IL‐29 by mast cells and modulation of mast cell behavior by IL‐29. Allergy 2010; 65: 1234–1241.
AbstractBackground: The role of interleukin (IL)‐29 in innate immunity has been recognized recently, and it is regarded as a potent bioactive molecule. However, little...
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