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Background Soft tissue sarcomas are a heterogeneous and rare group of solid tumors of mesenchymal origin that can arise anywhere in the body. Although surgical resection is the mainstay of treatment for patients with localized disease, disease recurrence is common and 5-year overall survival is poor (~ 65%). Both radiation therapy and conventional chemotherapy are used to reduce local and distant...
Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue sarcomas representing 6 major types. Along with novel insights into the biology of individual sarcoma types, we report three overarching findings: (1) unlike most epithelial malignancies, these sarcomas (excepting synovial sarcoma)...
There is a group of tumors which has been thought to include ‘histiocyte-like’, ‘fibroblast-like’and ‘myo-fibroblast-like’ cells that has been repeatedly expanded and collapsed over several decades as our methods of examining these tumors has advanced. In this review, we examine the history and present state of malignant fibrous histiocytoma.
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