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BACKGROUNDStromal–epithelial interactions are important in both development and prostate cancer. Stromal changes have been shown to be powerful prognostic indicators of prostate cancer progression and of patient death helping to define lethal versus indolent phenotypes. The specific molecular underpinnings of these interactions are incompletely understood. We investigated whether stromal cathepsin...
Metastatic diseases of prostate cancer reveal high expression of α6 integrin and the activation of mitogen-activated protein kinases (MAP kinase). Therefore, the present study was conducted to examine whether MAP kinase pathway is involved in the α6 integrin gene expression in androgen-independent prostate cancer cell lines. α6 integrin mRNA expression, the α6 integrin promoter-induced luciferase...
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