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Purpose
To assess the feasibility of CEST‐based creatine (Cr) mapping in brain at 3T using the guanidino (Guan) proton resonance.
Methods
Wild type and knockout mice with guanidinoacetate N‐methyltransferase deficiency and low Cr and phosphocreatine (PCr) concentrations in the brain were used to assign the Cr and protein‐based arginine contributions to the GuanCEST signal at 2.0 ppm. To quantify...
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