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We report an ultrahigh throughput multi-color microfluidic flow cytometer with 32 detection channels and 64 sheath-flow channels. This flow cytometer is realized by integrating a high N.A. microball lens array with a 3D microfluidic device, which allows introducing cell samples into 32 sample channels, and sheath flows into 64 channel for parallel microfluidic focusing using only two inlets. A throughput...
This paper reports an optofluidic tunable prism which is realized with two laminar flows in a microfluidic chip. By controlling the flow rate ratio between the two flows, the apex angle of the prism can be tuned continuously and therefore the deviation angle can be changed accordingly. A model for the hydrodynamic control is established for the prism. The optical deviation caused by the prism is theoretically...
We report on a new method to handle fluids in microfluidic systems by using both micro- aspiration and PDMS valves. Multilayer soft lithography technique has been used to fabricate microfluidic circuit and micro-aspiration network. We introduced micro-aspiration areas to locally create vacuum in the microfluidic network. The induced pressure differences can drive confined liquid into motion. This...
This paper gives a brief overview of silicon-based microfluidic platforms developed over the years by our group for the extraction, amplification, and detection of the nucleic acids. Extraction of both the genomic and viral nucleic acids from whole blood has been demonstrated on Si-based microfluidics. Rapid amplification has been achieved by polymerase chain reaction in Si-based thermal reactors...
Soft UV nanoimprint lithography has be used to fabricate third order Bragg gratings for visible light and microfluidic dye laser operation. Soft stamps has been made by casting a poly-dimethylsiloxane on a silicon mould and a bi-layer imprinting process has used to obtain resist patterns of high density and high aspect ration line-and-space features. After a lift-off of thin nickel film, reactive...
Among many others, absorbance measurement is one of the most useful techniques to determine sample concentration on a microfluidic chip. The main drawback of this technique comes from the limited optical path length that can be achieved on a chip. We propose here an original design of a microfluidic dye laser to perform intracavity absorption measurements. The effective optical path length and so...
The investigation of interactions between two kinds of monoclonal antibodies and SARS virus with a label-free protein array technique were presented in this paper. The performance consists of three parts: a surface modification for ligand immobilization/surface, a protein array fabrication with an integrated microfluidic system for patterning, packaging and liquid handling, and a protein array reader...
The concept of biosensor with imaging ellipsometry was proposed about ten years ago. It has become an automatic analysis technique for protein detection with merits of label-free, multi-protein analysis, and real-time analysis for protein interaction process, etc. Its principle, and related technique units, such as micro-array, micro-fluidic and bio-molecule interaction cell, sampling unit and calibration...
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