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Auto-regulatory transcriptional feedback, where the protein expressed from a gene inhibits its own transcription, is known to reduce stochastic fluctuations in protein numbers. Work has demonstrated the existence of negative feedback loops not only at the transcriptional level but also at the translational level. We investigate the noise suppression abilities of feedback loops at the translational...
Signaling by interleukin-6 (IL-6) involves two pathways: Janus-associated kinases (JAK) and signal transducers and transcription factors (STAT 3) are activated in the first pathway while the second pathway involves the activation of mitogen-activated protein kinases (MAPK). While it is recognized that both pathways play a major role in IL-6 signal transduction, simultaneous signaling through both...
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