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The action of riluzole, a neuroprotective drug, on cloned delayed rectifier K + channels (Kv1.5 and Kv3.1) was examined using the whole-cell patch-clamp technique. Riluzole reversibly inhibited Kv1.5 currents in a concentration-dependent manner with an IC 50 of 39.69±2.37μM. G-protein inhibitors (pertussis toxin and GDPβS) did not prevent this inhibition of riluzole on Kv1.5. No voltage-dependent...
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