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Elderly people often suffer adverse health because of inflammation associated with poor metabolism and cardiovascular dysfunction, but these conditions present differently in men and women. We performed experiments in aged male and female mice to understand this sexual dimorphism. We focused on sphingosine 1-phosphate (S1P) signaling, which has both protective and detrimental effects on vascular and...
Regulatory T (Treg) cells are plastic, but the in vivo mechanisms by which they are converted into foxhead box p3 (Foxp3 + ) interferon (IFN)-γ + T cells and whether these converted cells retain the ability to inhibit colitis are not clear.Foxp3 + Treg cells were generated by culture of naïve CD4 + T cells from Foxp3 GFP CBir1 T-cell receptor (TCR) transgenic...
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