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The APOE ɛ4 allele is a strong risk factor for Alzheimer's disease (AD). However, the molecular basis for this effect remains unclear. We examined expression of approximately 12,000 genes and expressed sequence tags in the hippocampus and cortex of PDAPP (APP V717 ) mice modeling AD that show extensive amyloid beta (Aβ) deposition, and in PDAPP mice lacking murine APOE expression, which show...
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