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Purpose: Activation of the myocardial, ATP-dependent potassium current (IKATP) during ischemia causes shortening of the action potential duration thereby increasing dispersion of repolarization between ischemic and non-ischemic myocardium and predisposing to reentrant arrhythmias. The IKATP inhibitor HMR1098 allows selective block of the sarcolemmal myocardial KATP-channel in various animal species...
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