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Our previous work revealed mutual and specific metabolites/pathways in artemisinin‐sensitive and ‐resistant Plasmodium berghei K173‐infected mice. In this study, we further investigated whether chrysosplenetin, a candidate chemical to prevent artemisinin resistance, can regulate these metabolites/pathways by integrating nontargeted metabolomics with 1H NMR and LC–Q‐TOF–MS/MS spectrum. The nuclear...
The reported method involves a novel workflow that eliminates the need for authentic reference standards for the quantitation of drug metabolites in biological samples using a single multi‐isotopically labeled compound bearing both radio and stable isotopes. The resulting radio and stable bifunctionalized isotopolog (RADSTIL) of the parent drug is employed as a substrate for in vitro biotransformation...
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