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Serotonin 2C receptors (5-HT 2C R) have been shown to undergo post-transcriptional RNA editing. This modification affects the affinity, coupling and constitutive activity of the receptor. In vivo, manipulations such as stress or antidepressant administration dramatically modify the pattern of 5-HT 2C R mRNA editing, suggesting that this phenomenon might be involved in the pathophysiology...
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