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The use of acoustic radiation force has been suggested for enhancing the delivery of therapeutic substances, whereas sonothrombolysis has been developed for years as treatment by itself, or in combination with thrombolytic agents or ultrasound contrast agents. We have examined the efficacy of using acoustic radiation force to enhance the targeting of microbubbles in cavitation-induced sonothrombolysis...
The thrombus-targeted ultrasound contrast agent with tirofiban, a glycoprotein IIb/IIIa antagonist that can specifically bind to activated platelets in the thrombus, was designed to enhance both the image contrast and the cavitation effect. The targeting ability to thrombi was confirmed by microphotography and high frequency ultrasound (40 MHz) images (3.34plusmn0.30 dB enhancement). Our inertial...
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