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In article number 1700818, Daesub Song, Seungjoo Haam, and co‐workers, propose poly (aniline‐co‐pyrrole) polymerized nanoregulators (PASomes) with an amphiphilic methoxy polyethylene glycol‐block‐polyphenylalanine co‐polymer (mPEG‐b‐pPhe) to regulate intracellular ROS levels. PASomes are water‐soluble, biocompatible, and could suppress viral infection, thereby increasing the cell survival rate.
Reactive oxygen species (ROS) produced during mitochondrial oxidative phosphorylation play an important role as signal messengers in the immune system and also regulate signal transduction. ROS production, initiated as a consequence of microbial invasion, if generated at high levels, induces activation of the MEK (mitogen‐activated protein kinase kinase)/ERK (extracellular signal‐regulated kinase)...
Vesicular pH modulates the function of many organelles and plays a pivotal role in cell metabolism processes such as proliferation and apoptosis. Here, we introduce a simple colorimetric redox-polyaniline nanoindicator, which can detect and quantify a broader biogenic pH range with superior sensitivity compared to pre-established trafficking agents employing one-dimensional turn-on of the fluorescence...
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