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Aims/hypothesis Existing thiazolidinedione (TZD) drugs for diabetes have severe side effects. The aim of this study is to develop alternative peroxisome proliferator-activated receptor γ (PPARγ) ligands that retain the benefits in improving insulin resistance but with reduced side effects. Methods We used AlphaScreen assay to screen for new PPARγ ligands from compound libraries. In vitro biochemical...
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