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The spiropyrrolizidine oximes 236 and 222 and a related spiropyrrolizidine alkaloid, nitropolyzonamine, block nicotinic receptor channels in rat pheochromocytoma PC12 cells and in human medulloblastoma TE671 cells. In PC12 cells with an α 3 β 4(5) -nicotinic receptor, both the spiropyrrolizidine oxime 236 and nitropolyzonamine had ic 50 values of about...
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