Search results for: S. Marieke Ham

Items from 1 to 10 out of 10 results

article

Suppressed IgG4 class switching in dupilumab‐ and TNF inhibitor‐treated patients after mRNA vaccination

Anika M. Valk, Jim B. D. Keijser, Koos P. J. Dam, Eileen W. Stalman, more

Allergy > 79 > 7 > 1952 - 1961

Background The noninflammatory immunoglobulin G4 (IgG4) is linked to tolerance and is unique to humans. Although poorly understood, prolonged antigenic stimulation and IL‐4‐signaling along the T helper 2‐axis may be instrumental in IgG4 class switching. Recently, repeated SARS‐CoV‐2 mRNA vaccination has been linked to IgG4 skewing. Although widely used immunosuppressive drugs have been shown to only...

article

Ocrelizumab Concentration Is a Good Predictor of SARS‐CoV‐2 Vaccination Response in Patients with Multiple Sclerosis

Zoé L. E. Kempen, Laura Hogenboom, Alyssa A. Toorop, Maurice Steenhuis, more

Annals of Neurology > 93 > 1 > 103 - 108

Ocrelizumab, an anti‐CD20 monoclonal antibody, counteracts induction of humoral immune responses after severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) vaccinations in patients with multiple sclerosis (MS). We aimed to assess if serum ocrelizumab concentration measured at the time of vaccination could predict the humoral response after SARS‐CoV‐2 vaccination. In 52 patients with MS, we...

article

Termination of CD40L co‐stimulation promotes human B cell differentiation into antibody‐secreting cells

Casper Marsman, Niels JM Verstegen, Marij Streutker, Tineke Jorritsma, more

European Journal of Immunology > 52 > 10 > 1662 - 1675

Human naïve B cells are notoriously difficult to differentiate into antibody‐secreting cells (ASCs) in vitro while maintaining sufficient cell numbers to evaluate the differentiation process. B cells require T follicular helper (T_FH) cell‐derived signals like CD40L and IL‐21 during germinal center (GC) responses to undergo differentiation into ASCs. Cognate interactions between B and T_FH cells are...

article

Divergent chemokine receptor expression and the consequence for human IgG4 B cell responses

Peter‐Paul A. Unger, Laura C. Lighaam, Ellen Vermeulen, Simone Kruithof, more

European Journal of Immunology > 50 > 8 > 1113 - 1125

IgG4 antibodies are unique to humans. IgG4 is associated with tolerance during immunotherapy in allergy, but also with pathology, as in pemphigus vulgaris and IgG4‐related disease. Its induction is largely restricted to nonmicrobial antigens, and requires repeated or prolonged antigenic stimulation, for reasons poorly understood. An important aspect in generating high‐affinity IgG antibodies is chemokine...

article

Correction to: Autologous tumor cell vaccination combined with systemic CpG-B and IFN-α promotes immune activation and induces clinical responses in patients with metastatic renal cell carcinoma: a phase II trial

Bas D. Koster, Saskia J. A. M. Santegoets, Jorien Harting, Arnold Baars, more

Cancer Immunology, Immunotherapy > 2019 > 68 > 6 > 1037-1037

In the original publication of the article the following abstract and keywords were inadvertently omitted.

article

Autologous tumor cell vaccination combined with systemic CpG-B and IFN-α promotes immune activation and induces clinical responses in patients with metastatic renal cell carcinoma: a phase II trial

Bas D. Koster, Saskia J. A. M. Santegoets, Jorien Harting, Arnold Baars, more

Cancer Immunology, Immunotherapy > 2019 > 68 > 6 > 1025-1035

article

The role of pathogen‐reduced platelet transfusions on HLA alloimmunization in hemato‐oncological patients

Anno Saris, Jean Louis Kerkhoffs, Philip J. Norris, S. Marieke Ham, more

Transfusion > 59 > 2 > 470 - 481

BACKGROUND Platelet transfusions can induce alloimmunization against HLA antigens. The use of pathogen‐reduced platelet concentrates (PCs) was suggested to reduce HLA alloimmunization and concomitant transfusion refractoriness. METHODS This study investigated HLA alloimmunization in available samples from 448 hemato‐oncological patients who were randomized for the Pathogen Reduction Evaluation...

article

Alternative Ii-independent antigen-processing pathway in leukemic blasts involves TAP-dependent peptide loading of HLA class II complexes

Marvin M. Luijn, Martine E. D. Chamuleau, Maaike E. Ressing, Emmanuel J. Wiertz, more

Cancer Immunology, Immunotherapy > 2010 > 59 > 12 > 1825-1838

During HLA class II synthesis in antigen-presenting cells, the invariant chain (Ii) not only stabilizes HLA class II complexes in the endoplasmic reticulum, but also mediates their transport to specialized lysosomal antigen-loading compartments termed MIICs. This study explores an alternative HLA class II presentation pathway in leukemic blasts that involves proteasome and transporter associated with...

article

Monophosphoryl lipid A plus IFNγ maturation of dendritic cells induces antigen-specific CD8⁺ cytotoxic T cells with high cytolytic potential

Anja Brinke, Gijs Schijndel, Remco Visser, Tanja D. Gruijl, more

Cancer Immunology, Immunotherapy > 2010 > 59 > 8 > 1185-1195

Dendritic cells (DCs) are promising antigen presenting cells for cancer treatment. Previously, we showed that the combination of monophosphoryl lipid A (MPLA) with IFNγ generates mature DCs that produce IL-12 and polarize CD4⁺ T cells towards a Th1 phenotype. Here, we extended these observations by showing that the DCs generated with the clinical grade maturation cocktail of MPLA/IFNγ induce superior...

article

An ex vivo readout for evaluation of dendritic cell-induced autologous cytotoxic T lymphocyte responses against esophageal cancer

Francesca Milano, Agnieszka M. Rygiel, Navtej Buttar, Jacques J. G. H. M. Bergman, more

Cancer Immunology, Immunotherapy > 2007 > 56 > 12 > 1967-1977

Esophageal cancer is a highly malignant disease that despite surgery and adjuvant therapies has an extremely poor outcome. Dendritic cell (DC) immunotherapy as a novel promising strategy could be an alternative for treating this malignancy. Effective DC-mediated immune responses can be achieved by raising cytotoxic T lymphocyte (CTL) response against multiple antigens through loading DCs with total...

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