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Objective
The gold standard for measuring blood‐retinal barrier permeability is the Evans blue assay. However, this technique has limitations in vivo, including non‐specific tissue binding and toxicity. This study describes a non‐toxic, high‐throughput, and cost‐effective alternative technique that minimizes animal usage.
Methods
Sodium fluorescein fundus angiography was performed in non‐diabetic...
Key points
We have developed novel techniques for paired, direct, real‐time in vivo quantification of endothelial glycocalyx structure and associated microvessel permeability.
Commonly used imaging and analysis techniques yield measurements of endothelial glycocalyx depth that vary by over an order of magnitude within the same vessel.
The anatomical distance between maximal glycocalyx label and...
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