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The melanocortin peptides α-MSH, Lys-Pro-Val and Lys-Pro-d-Val are known to be potent anti-inflammatory agents; however their role as antibacterial peptides is less clear. The aim of this study was to determine whether these peptides displayed antibacterial properties, and specifically whether the Lys-Pro-d-Val tripeptide was more potent than Lys-Pro-Val, consistent with their anti-inflammatory actions...
Alpha-melanocyte stimulating hormone (α-MSH) arises from the proteolytic cleavage of proopiomelanocortin (POMC) and is the most potent naturally occurring melanotropic peptide. The biological effects of α-MSH are mediated via melanocortin receptors (MCRs), which are expressed in virtually every cutaneous cell type. α-MSH has pleiotrophic functions including the modulation of a wide range of inflammatory...
Alpha-melanocyte stimulating hormone (α-MSH) has been identified as a potent anti-inflammatory peptide effective in various tissues including skin. It acts by inhibiting the production and action of several pro-inflammatory stimuli including TNF-α, IL-1β and LPS in a number of cell types. The role of such stimuli in inducing cellular apoptosis is also well described; however the precise role of α-MSH...
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