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Adipocyte deposition is a key feature of age‐related thymic involution, but the underlying mechanisms responsible for thymic adiposity remain to be elucidated. In the present study, we utilized rosiglitazone, a potent peroxisome proliferator‐activated receptor γ agonist, to induce adipogenic differentiation of OP9‐DL1 cells, and detected the metabolomics alterations during adipogenic differentiation...
Age‐related thymic involution is characterized by a loss of thymic epithelial cells (TECs) and a concomitant increase in adipocytes, but the mechanisms involved in thymic adipogenesis are still not clear. Transforming growth factor β1 (TGF‐β1) is a pleiotropic cytokine that has been reported to be up‐regulated with age in thymic stromal cells in both human and mouse. However, the exact role of TGF‐β1...
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