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Single nucleotide polymorphisms (SNPs) that can alter phenotypes of individuals play a pivotal role in disease development and, more importantly, responses to therapy. However, SNP genotyping has been challenging due to the similarity of SNP alleles and their low concentration in biological samples. Sequence‐specific nanoparticle with interpretative toehold‐mediated sequence decoding in hydrogel (SWITCH)...
SNP Genotyping
In article number 2105538, Jungkyu Choi, Hyojin Lee, Nakwon Choi, an co‐workers present SWITCH for multiplex single nucleotide polymorphism genotyping. Invaders (single‐stranded oligonucleotides, colored in blue and yellow) obtained from a gold nanoparticle induce fluorescence recovery in specific regions of a shape‐coded hydrogel microparticle.
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