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BackgroundPolyhydroxybutyrate (PHB), an important member of the family of polyhydroxyalkanoates (PHAs), is a biodegradable thermoplastic synthesized by numerous microorganisms under different cultivation conditions.
ResultsA simple dynamic model for producing PHB in a fed‐batch reactor is presented. The kinetic model accuracy is quantified by the specific error measures. The dynamic manipulation scheme with prescribed stepwise changes is used to improve PHB productivity. A multi‐objective optimization algorithm is used to determine the optimal feeding strategy...
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