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Selective targeting of bone marrow-derived cells (BMCs) has been heralded as a promising avenue for age-related macular degeneration (AMD) therapeutics. Many researchers have demonstrated that the function of circulating BMCs is related to disease severity in patients with AMD. Transplanted BMCs are able to transdifferentiate into retina-specific cells to replace those lost due to damage or degeneration...
Diabetes mellitus (DM) can cause many systemic complications, including proliferative diabetic retinopathy (PDR). Retinal neovascularization (RNV) is the typical symptom of PDR, representing an important risk factor for severe vision loss in patients with DM. Diabetic hyperglycemia plays a major role in the destruction of retinal capillary walls, resulting in retinal ischemia and up-regulation of...
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