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Chronic hepatitis B infection remains incurable due to the stable presence of various forms of hepatitis B virus (HBV) genome, especially the HBV covalently closed circular DNA (cccDNA). The emergence of clustered regularly interspaced short palindromic repeat (CRISPR) technology provides a new opportunity to potentially cure the HBV infection. However, the efficiency and specificity remain unsatisfactory,...
Spatiotemporal Liver Genome Editing
In article number 2210860, Mingqiang Li, Yu Tao, Yeh‐Hsing Lao, and co‐workers report spatiotemporally‐controlled gene editing to inactivate hepatitis B infection based on magnetic nanoparticles and liver‐specific promoter‐driven CRISPR/Cas9 plasmid. The nanosystem improves targeting at the tissue level, while the liver‐specific promoter offers additional specificity...
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