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The majority of CXCR5+PD1+CD4+ T follicular helper (Tfh) cells (>90%) are CD25−Bcl6hi, while a small subpopulation (<10%) are CD25+Bcl6low but do not express FoxP3 and are not T regulatory cells. We purified T:B‐cell conjugates from tonsils and found they were enriched for the CD25+Bcl6low Tfh‐cell subpopulation. In response to IL‐2, these CD25+ Tfh cells increased expression of costimulatory...
Human peripheral blood Vγ2Vδ2 T cells are important for host defence and tumour immunity. Their unusual T‐cell receptor (TCR) recognizes small molecule phosphoantigens; stimulated cells produce inflammatory cytokines and are potently cytotoxic for a variety of tumours. However, molecular mechanisms linking phosphoantigen stimulation and cytotoxicity are incompletely understood. We know that isopentenyl...
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