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Objective
To compare in a randomised, open‐label, non‐inferiority clinical study, the efficacy and tolerability of Serenoa repens (SeR) + selenium (Se) + lycopene (Ly) (SeR‐Se‐Ly) therapy vs tadalafil 5 mg in men with lower urinary tract symptoms (LUTS).
Patients and methods
From May 2015 to January 2017, 427 patients were enrolled in 21 different centres (International Standard Randomised Controlled...
BACKGROUNDPhytotherapy has been used to treat patients with lower urinary tract symptoms (LUTS). We evaluated the efficacy and tolerability of combination therapy between Serenoa Repens (SeR), Lycopene (Ly), and Selenium (Se) + tamsulosin versus single therapies.
METHODSPROCOMB trial (ISRCTN78639965) was a randomized double‐blinded, double‐dummy multicenter study of 225 patients between 55 and 80...
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