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Hypoxia and acidosis are recognized features of inflammatory arthroses. This study describes the effects of IGF‐1 and TGF‐β1 on pH regulatory mechanisms in articular cartilage under hypoxic conditions. Acid efflux, reactive oxygen species (ROS), and mitochondrial membrane potential were measured in equine articular chondrocytes isolated in the presence of serum (10% fetal calf serum), IGF‐1 (1, 10,...
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