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Background Inhaled nitric oxide (INO), a selective pulmonary vasodilator, has revolutionized the treatment of neonatal hypoxemic respiratory failure (NHRF). However, there is lack of sustained improvement in 30 to 46% of infants. Aerosolized prostaglandins I 2 (PGI 2 ) and E 1 (PGE 1 ) have been reported to be effective selective pulmonary...
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