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A new series of 12-benzyl matrinic amide/ethanamide derivatives were synthesized from matrinine (1) and evaluated for their anti-HCV activity, taking compound 2 as the lead. SAR revealed that the introduction of a suitable substituent at the N′-end of matrinic amide might greatly enhance the potency. Among them, matrinic acid 17 and N′-substituted matrinic amides 18a–d exhibited promising potency...
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