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A universal central nervous system (CNS)‐delivery platform is developed enabling the delivery of protein therapeutics to the brain via choline transporters and acetylcholine receptors. In article number 1807557, Zhanlong He, Jing Wen, Wei Chen, Yunfeng Lu, and co‐workers demonstrate that the protein therapeutics can effectively penetrate the blood–brain barrier in mice and nonhuman primates by encapsulating...
Central nervous system (CNS) diseases are the leading cause of morbidity and mortality; their treatment, however, remains constrained by the blood–brain barrier (BBB) that impedes the access of most therapeutics to the brain. A CNS delivery platform for protein therapeutics, which is achieved by encapsulating the proteins within nanocapsules that contain choline and acetylcholine analogues, is reported...
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