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To determine the contribution of antibodies to angiotensin II type 1 receptor (AT1R-Ab) and anti-endothelial cell antibody (AECAs) in patients receiving an incompatible kidney transplant, defined as presence of donor specific HLA antibodies(HLA-DSA) or ABO incompatibility between donor and recipient.AT1R-Ab and AECAs were evaluated prior to transplantation for 54 recipients of an incompatible kidney...
Antibody to donor HLA antigens is a significant barrier to both access to and outcome of allogeneic transplants. Many attempts have been made to desensitize patients with HLA-specific antibody, but the most effective and durable have been treatment with high-dose pooled human intravenous immunoglobulin (IVIg) and a combination of plasmapheresis and low-dose IVIg. Despite the success of these treatments,...
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