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Mononuclear phagocytes (MNPs) are a highly heterogeneous group of cells that play important roles in maintaining the body’s homeostasis. Here, we found CD301b (also known as MGL2), a lectin commonly used as a marker for alternatively activated macrophages, was selectively expressed by a subset of CD11b+CD11c+MHCII+ MNPs in multiple organs including adipose tissues. Depleting CD301b+ MNPs in vivo led...
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