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The hypersensitive response (HR) is a robust immune response mediated by nucleotide‐binding, leucine‐rich repeat receptors (NLRs). However, the early molecular event that links activated NLRs to cell death is unclear.
Here, we demonstrate that NLRs target plasma membrane H+‐ATPases (PMAs) that generate electrochemical potential, an essential component of living cells, across the plasma membrane...
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