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In order to determine the mechanism of action of the 27 kDa mosquitocidal δ-endotoxin of Bacillus thuringiensis var. israelensis we have studied its effects on the conductance of planar lipid bilayers. The toxin formed cation-selective channels in the bilayers, permeable to K + and Na + but not to N-methylglucamine or Cl - , showing very fast, cooperative opening and closing...
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