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Purpose: Solid and necrotic brain tumors respond to radiosurgery, although necrotic lesions often contain a significant proportion of hypoxic cells which cannot become reoxygenated during the short overall treatment time of single dose application. In addition to the direct cytotoxic action, delayed vascular occlusion followed by ischemic tumor cell death could contribute to the effect of radiosurgery...
Patients (pts) with brain metastases have a high risk of cancer-related death due to extra- or intracranial tumor manifestations. The present retrospective analysis demonstrates the ability of linear accelerator (LINAC)-based radiosurgery to control intracranial disease and prolong survival in pts with one to three metastases. From 1991 to 1996, 106 pts (42 females, 64 males; median age, 57 years)...
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