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Bilirubin and its metabolic precursor biliverdin are heme degradation products but have been proposed as physiological antioxidants. Reports from another laboratory as well as from ours have shown bilirubin to form a complex with the transition metal ion-Cu(II). Such a complex was shown by us to cause oxidative DNA damage. Further, biliverdin was also shown to be capable of causing similar DNA damage...
Resveratrol (3,4',5-trihydroxy stilbene) is a phytoalexin and a polyphenolic compound present in human dietary material such as peanuts, mulberries, grapes and red wine. It is widely considered to possess cardiovascular protective properties and has also been shown to be chemopreventive against various stages of chemically induced carcinogenesis. It has recently been shown that resveratrol induces...
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