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In the process of developing drugs, proof‐of‐concept studies can be helpful in determining whether there is any evidence of a dose‐response relationship. A global test for this purpose that has gained popularity is a component of the multiple comparisons procedure with modeling techniques (MCP‐Mod), which involves the specification of a candidate set of several plausible dose‐response models. For...
We consider a study‐level meta‐analysis with a normally distributed outcome variable and possibly unequal study‐level variances, where the object of inference is the difference in means between a treatment and control group. A common complication in such an analysis is missing sample variances for some studies. A frequently used approach is to impute the weighted (by sample size) mean of the observed...
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