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The aim of this study was to investigate possible sodium triple‐quantum (TQ) signal dependence on pH variation and protein unfolding which may happen in vivo. The model system, composed of bovine serum albumin (BSA), was investigated over a wide pH range of 0.70 to 13.05 and during urea‐induced unfolding. In both experimental series, the sodium and BSA concentration were kept constant so that TQ signal...
Background
Triple‐quantum (TQ) filtered sequences have become more popular in sodium MR due to the increased usage of scanners with field strengths exceeding 3T. Disagreement as to whether TQ signal can provide separation of intra‐ and extracellular compartments persists.
Purpose
To provide insight into TQ signal behavior on a cellular level.
Study Type
Prospective.
Phantom/Specimen
Cell‐phantoms...
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