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Interferon regulatory transcription factor 1 (IRF‐1) regulates downstream signals of tumor necrosis factor α (TNF‐α). The activity of IRF‐1 is mediated by Jak/Stat signaling pathway. In this study, we found that PPAR γ coactivator‐1α (PGC‐1α) is able to suppress the induction of IRF‐1. Treatment with TNF‐α in MC3T3 cells leads to a sustainable increase in the expression of IRF‐1 and its target gene...
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