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Classical Hodgkin lymphoma (CHL) is morphologically characterized by scattered malignant Hodgkin/Reed–Sternberg (HRS) cells that are far outnumbered by surrounding reactive hematolymphoid cells. Approximately half of all cases of CHL are associated with infection by Epstein–Barr virus (EBV), an oncogenic herpesvirus that expresses a number of proteins thought to contribute to transformation. While...
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