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Neutralizing antibodies and cellular immune response both play essential roles in the clearance of Hepatitis C virus (HCV) infection. The envelope glycoprotein E2 is a major target for producing neutralizing antibodies against HCV. Here, we constructed a recombinant plasmid, termed pcDNA3.1‐E2‐Fc, to express HCV E2 with an immunoglobulin Fc fusion tag (E2‐Fc). Importantly, we found that the titers...
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